Enfamil NeuroPro Vs Similac Pro Advance

Are you trying to decide between Enfamil NeuroPro vs Similac Pro Advance baby formulas?

Then let us help you decide which is best formula for you and your baby with our Similac Pro Advance vs Enfamil Neuropro review!

Take a quick look at any tub of infant formula, and you’re going to discover a long list of ingredients and benefits. Trying to decipher them all can feel impossible, especially as every brand claims to be the best of the best.

If you’re trying to choose a formula, then you’ve undoubtedly come across Enfamil and Similac. These are two of the most popular brands on the market, and the NeuroPro and Pro-Advance range make some big claims about supporting your baby’s development.

In this guide, we’ve taken a close look at Enfamil NeuroPro vs Similac Pro-Advance, to see exactly what these two formulas are offering, including their features, pros, and cons.

And if you love this review on the difference between Similac Pro Advance and Enfamil Neuropro, then make sure to check out our guides on Similac Pro Total Comfort Vs Pro SensitiveEnfamil Gentlease vs Similac SensitiveEnfamil Sensitive Vs Gentlease and Enfamil Gentlease vs Neuropro!

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similac pro advance vs enfamil neuropro

Enfamil NeuroPro Vs Similac Pro Advance

Let’s get started by seeing what Enfamil NeuroPro and Similac Pro-Advance have to offer.

All About Enfamil NeuroPro

Enfamil NeuroPro is an advanced nutritional feed designed to mimic breast milk as closely as possible. Offering support for both the brain and the immune system, Enfamil NeuroPro provides a complete feed to help your little one discover the world safely.

Enfamil have created NeuroPro with the help of clinical studies, to recreate the formulation of breast milk as closely as possible. This formula contains Omega 3 DHA, a fatty acid found in breast milk. Omega 3 DHA is recommended by experts thanks to its extensive brain building properties, supporting development until age 5!

NeuroPro is packed full of goodness, including an exclusive HuMO6 blend. This immune supporting blend contains ingredients such as 2’FL-HMO, Selenium, PDX, and GoS. Alongside MFGM, this blend closely mimics breast milk, and helps develop a robust immune system.

All these benefits do come with one slight downside — Enfamil NeuroPro is a relatively expensive formula. While you get a lot packed into Enfamil NeuroPro, there are other options for a nutritionally complete feed at a lower price.

You may also like this post on Enfamil Enspire Vs Neuropro.


  • Enfamil NeuroPro supports brain development with brain building Omega 3 DHA.
  • Closely mimics breast milk with the addition of an exclusive HuMO6 immune blend.
  • Contains MFGM, a fat found in breast milk.
  • Made with non-GMO ingredients.
  • A triple prebiotic immune blend of 2’-FL HMO, PDX, and GoS supports immune development.


  • Enfamil NeuroPro is quite expensive for a formula.
  • Contains palm olein oil, which can limit the absorption of calcium.
Enfamil NeuroPro Baby Formula
$187.96 ($1.66 / Ounce)
02/23/2024 02:03 am GMT

All About Similac Pro Advance

Similac Pro-Advance is an addition to the popular Similac Pro range, designed to be closer to breast milk than ever before. It’s boosted with the addition of 2’-FL HMO, a prebiotic which supports the healthy development of the immune system.

Alongside 2’-FL HMO, Similac Pro-Advance contains the Similac exclusive blend of DHA, lutein, and vitamin E. These three ingredients, found in breast milk, work together to support healthy brain and eye development in children.

As much as we love the ingredients added into the formula, parents also love the ingredients kept out of Similac Pro-Advance. This formula blend is made without artificial growth hormones, and contains no genetically modified ingredients. It also contains no palm olein oil. This is often added to build the fats in formula, but it can limit the absorption of calcium. By leaving it out, Similac Pro-Advance supports strong bones.


  • Similac Pro-Advance contains 2’-FL HMO, a prebiotic that assists immune development.
  • Formulated with the Similac exclusive blend of DHA, lutein, and vitamin E, for brain and eye development.
  • Promoted calcium absorption and strong bones by removing palm olein oil.
  • Contains no GMO ingredients, and no artificial growth hormones.
  • Well priced for a 2’-FL HMO formula.


  • Similac Pro-Advance is a nutritionally complete formula, but it lacks the brain boosting ingredients of Enfamil NeuroPro.

Similarities And Difference Between Similac Pro Advance And Enfamil Neuropro

Enfamil NeuroPro and Similac Pro-Advance are both popular choices with parents. In this section, we’ll take a closer look at the important similarities, and the details that set them apart.

A Nutritional Feed

The first thing to note is that both Enfamil NeuroPro and Similac Pro-Advance do provide a complete and supportive feed. While there are notable differences between the brands, the biggest similarity is the care they’ll provide your baby.

Enfamil is the number one infant formula brand recommended by pediatricians. Inspired by breast milk, this brand provides well rounded support for a growing baby. Similac also comes highly recommended, and has been trusted by parents for over 90 years.

When choosing between Enfamil NeuroPro and Similac Pro-Advance, you can feel confident knowing both options provide a healthy and nutritional feed for your baby. So, you can really focus on the details when making a decision!

Brain Development

Enfamil NeuroPro has been specially created to support the brain in these very early stages, and to keep on supporting your little one as they grow.

Enfamil NeuroPro contains expert recommended Omega 3 DHA. This is an important fatty acid for the brain, and the Omega 3 DHA in Enfamil NeuroPro can provide long term brain development. In fact, the DHA in the NeuroPro formula can support the brain until your little one is age 5, and not quite so little!

Enfamil NeuroPro also contains milk fat globule membrane, or MFGM. This is a fat that occurs naturally in breast milk, and, like DHA, helps build the brain.

Similac Pro-Advance isn’t quite so structured towards brain development (we’ll cover the main benefits of Pro-Advance below), but it is supportive toward building a healthy brain. Similac Pro-Advance contains an exclusive blend of DHA, lutein, and vitamin E. As with Enfamil NeuroPro, DHA is added to Pro-Advance for its brain boosting powers. Lutein and vitamin E help support eye development.

Enfamil NeuroPro really emphasizes the brain building ingredients, but Similac Pro-Advance still offers plenty of support!

Immune Development

Similac Pro-Advance is a nutritional feed designed to strengthen and develop your baby’s immune system. It’s formulated with 2’-FL human milk oligosaccharide (HMO), a prebiotic that is found in abundance in breast milk. 2’-FL HMO helps to strengthen the immune system, protecting your baby against illness.

Enfamil NeuroPro is formulated with an exclusive HuMO6 blend, designed specifically to support the immune system. This blend includes 2’FL-HMO, PDX, GoS, vitamins C and E, and Selenium.

These ingredients help make these formulas as close to breast milk as possible. By developing a healthy immune system, your little one is ready to take on the world!

Other Nutritional Additions

Take a glance at the back of any formula packet, and you’re going to be confronted with a long list of ingredients. Let’s take a closer look at what you’re actually getting with Enfamil NeuroPro and Similac Pro-Advance.

Overall, Similac Pro-Advance contains slightly more protein (2.07g per serving, compared to 2g), and higher levels of fat (5.6g compared to 5.3g). Both brands use nonfat milk and lactose as a protein base, with vegetable oils providing the fat content. Enfamil contains a mixture of palm olein, coconut, sot, and high oleic sunflower oil, while Similac Pro-Advance uses high oleic safflower oil, soy, and coconut oil.

One advantage to Similac Pro-Advance is the ingredients it doesn’t use. Pro-Advance contains no palm olein oil, which can limit the absorption of calcium. By leaving this ingredient out, Similac Pro-Advance supports better bone development.

Pro-Advance is also free from artificial growth hormones, and contains no genetically modified ingredients. Enfamil NeuroPro is also free from GMO ingredients, but there’s no mention of artificial growth hormones. (Artificial growth hormones are often given to cows, which provide the milk that forms the base of the formula.)

Ease Of Digestion

Digestion issues are common in young babies, as the developing stomach struggles with new proteins and foods.

If your little one has a sensitive stomach, you might prefer non-lactose infant formulas. Both Enfamil NeuroPro and Similac Pro-Advance are milk- and lactose-based, meaning they can be harder to digest.

While both brands should be gentle on your baby’s tummy, they aren’t designed for easing digestive issues. For most parents, this won’t be a problem, but it’s worth remembering if you’ve struggled to find a formula that works.


There’s very little price difference between Enfamil NeuroPro and Similac Pro-Advance, but Similac Pro-Advance is typically a few cents cheaper. This might not seem like much upfront, but you’re likely to go through a lot of infant formula over the months. Those few cents can add up to a noticeable difference.

Final Thoughts On Similac Pro Advance vs Enfamil Neuropro

Both Enfamil NeuroPro and Similac Pro-Advance are supportive formulas that contain a healthy boost of vitamins, prebiotics, and overall goodness. No matter which formula you choose, you’ll be making a smart choice for your little one.

With that said, our top pick is Enfamil NeuroPro. This formula closely mimics breast milk, and the HuMO6 blend provides excellent immune support. This is a formula that really goes the extra distance to support your baby.

However, Similac Pro-Advance is more affordable, and this well-formulated blend offers exceptional support.

We hope this guide has helped you understand the differences between Enfamil NeuroPro and Similac Pro-Advance so you can make the best choice for you and your baby.

And if you want to check out any more of our guides, we recommend checking out these guides on  best formula that tastes like breast milkhow to keep baby bottle warm at night and how to warm bottles on the go. Or even our guides for the best bottles for tongue tie, and best baby bottles for reflux.

Enfamil NeuroPro Baby Formula
$187.96 ($1.66 / Ounce)
02/23/2024 02:03 am GMT
enfamil neuropro vs similac pro advance