Enfamil Gentlease Vs Similac Sensitive

Are you trying to decide between Enfamil Gentlease vs Similac Sensitive infant formula to help soothe a fussy baby?

Then let us help you decide which is best baby formula for you baby’s sensitive stomach with our Similac Sensitive or Enfamil Gentlease review!

Choosing the right formula for your baby can feel like an intimidating choice. There are so many options to choose from, and all babies have different wants and needs.

If your little one is struggling with a sensitive stomach, the choice gets even harder!

Enfamil Gentlease and Similac Sensitive are infant formulas created to help ease digestion for delicate tummies. Both brands are popular with parents and healthcare professionals, offering a complete feed for sensitive stomachs.

In this guide, we’ll explore the differences and similarities between Enfamil Gentlease and Similac Sensitive as well as their pros and cons so you can easily decide which formula is right for your family!

And if you love this Similac sensitive vs Enfamil Gentlease review, make sure to check out our guides on best formula that tastes like breast milk, Similac Pro Total Comfort Vs Pro SensitiveEnfamil Sensitive Vs Gentlease and Enfamil Gentlease vs Neuropro!

This post contains affiliate links. See our full disclosure here

enfamil gentlease vs similac sensitive

Enfamil Gentlease Vs Similac Sensitive

We’ll begin by exploring what Enfamil Gentlease and Similac Sensitive have to offer.

All About Enfamil Gentlease 

Enfamil Gentlease is an infant formula designed to ease fussing, crying, and excessive gas. Created using easy-to-digest ingredients, Enfamil Gentlease helps sensitive stomachs break down tough proteins.

Enfamil Gentlease is made using a base of partially hydrolyzed milk and whey proteins. These are proteins that have already been partly broken down.

So, when they reach the stomach, there’s less work for the body to do. Digestion is made easier, for less fussing, and happier feeding times.

Thanks to these partially hydrolyzed proteins, Enfamil Gentlease is an excellent formula for babies suffering from general stomach sensitivities. It’s also a fantastic all around formula.

A complete blend of proteins and nutrients ensure your little one is getting everything they need. And the addition of choline and DHA supports healthy brain growth!

Enfamil Gentlease mixes quickly, with a thin consistency that is easy for babies to enjoy. Gentlease is also affordable, particularly for a formula aimed at delicate stomachs.

However, if your little one has a lactose sensitivity, the partially hydrolyzed milk proteins of Enfamil Gentlease might cause problems.


  • Made using partially hydrolyzed milk and whey proteins, which are easier to digest.
  • Works quickly, and can potentially reduce fussiness in just 24 hours.
  • Contains added choline and DHA to support brain development.
  • An affordable choice for sensitive stomachs.
  • The number one pediatrician recommended brand for gassy and fussy babies.


  • Contains milk proteins.
  • Some parents report a strong smell.

You may also like our Enfamil AR Vs Gentlease and Enfamil Gentlease alternative reviews!

All About Similac Sensitive

Lactose is a sugar found in milk and dairy that some stomachs struggle to digest. And when the body can’t break lactose down, feeding starts to feel uncomfortable.

Lactose sensitivities can cause babies to become fussy, gassy, and to spit-up.

Similac Sensitive is an infant formula designed for babies with lactose sensitivity. It uses milk protein isolate as a base.

Essentially, this is dairy with the lactose removed. It has all the nutritional benefits of standard milk, but without that tricky lactose.

By using milk protein isolate, Similac Sensitive is a reasonably affordable solution for babies with lactose intolerance. It’s also packed full of good things.

The complete blend of nutrients is boosted with the addition of DHA, lutein, and vitamin E, to support the brain and eyes.

The Similac brand is popular with parents, and the number one infant formula brand fed in hospitals.

However, the Similac Sensitive formula is a little thick when mixed, and has a tendency to foam. It won’t be a problem for most parents, but some have had issues.


  • Made with milk protein isolate, to remove the lactose while keeping the nutrients.
  • Contains DHA, lutein, and vitamin E, to support brain and eye development.
  • No palm olein oil, for better calcium absorption.
  • The number one infant formula brand fed in hospitals.
  • Specially formulated for lactose sensitivities.


  • Thick when mixed.
  • Has a tendency to foam.

You may also like our review on Similac Sensitive vs Pro Sensitive!

Similac Sensitive Infant Formula
$47.81 ($0.25 / Fl Oz)
05/23/2024 12:03 pm GMT

Similarities And Differences Between Enfamil Gentlease And Similac Sensitive

In this section, we’ll take a closer look at the similarities between the brands, as well as those all important differences. 

Pediatrician Recommended

Whether you choose Enfamil Gentlease or Similac Sensitive, the first thing you should know is that both formulas come highly recommended.

Similac is the number one hospital fed brand, while Enfamil Gentlease is the number one pediatrician recommended brand for gassy and fussy babies!

We know that as parents, you always want to do what’s best for your baby. Both Enfamil and Similac are trusted brands, carefully created to support your little one’s needs.

So, when you’re making your choice, you can feel comfortable knowing that you’re already off to a good start! 

Enfamil and Similac are both excellent choices for babies with sensitive stomachs (it’s just a case of finding which one works for your family)!

Nutrient Rich

One of the reasons both Enfamil Gentlease and Similac Sensitive come so highly recommended is due to their careful blend of supportive nutrients. The brands do use a slightly different balance of nutrients, but both options provide a complete feed. 

Enfamil Gentlease emphasizes their use of choline and DHA. These nutrients are designed to nourish the brain, supporting those important early months of growth.

DHA is an omega-3 fatty acid, while choline is essential for supporting the membranes surrounding your cells.

Similac Sensitive is boosted with the Similac exclusive blend of DHA, lutein, and vitamin E. These nutrients support brain and eye development. Lutein and vitamin E are both important nutrients for eye health. 

Easy Digestion

If you’re considering buying Enfamil Gentlease or Similac Sensitive, it’s likely because you’ve struggled with more traditional formulas.

Both these choices are created specifically for babies with sensitive stomachs, who might have had issues digesting standard milk-based formulas.

Enfamil Gentlease is created using partially hydrolyzed nonfat milk and whey proteins. Hydrolyzation is essentially the process of breaking things down.

So, partially hydrolyzed proteins are partly broken down. This is easier for the body to digest, as it has less work to do!

Similac Sensitive uses milk protein isolate. This is created using a filtering process that removes the lactose sugars from the milk. Lactose sensitive stomachs can then digest the protein, without the lactose!

Both these formulas use proteins that are carefully treated to make them easier for bodies to digest. Doing so can reduce fussiness, and ensure even sensitive stomachs are getting the nutrients they need.  

You may also like our guide on Enfamil Gentlease vs Similac Total Comfort!


Babies go through a lot of formula, and even small price differences can quickly add up. 

Enfamil Gentlease is typically more cost effective than Similac Sensitive. Honestly, the price difference isn’t much — we’re talking a couple of cents per oz.

But over the months, you might find those few cents can make a difference. 

Enfamil Gentlease and Similac Sensitive are both available in bulk packs for a lower price, but we recommend starting with a smaller purchase.

While both these formulas are designed for sensitive tummies, you can never quite tell how your little one will react. Once you know you’ve made the right choice, you can start to use bulk buys to make savings. 

Taste And Texture

Enfamil Gentlease is a thinner formula, which is easier for babies to suck from the bottle. Similac Sensitive is just that bit thicker, and some babies might find it frustratingly hard to get at! 

Some parents have also found that Similac Sensitive has a strong taste, and it can be a little divisive. It’s impossible to know what your baby will enjoy, so don’t let taste be the deciding factor.

However, if you have struggled to find a formula for a picky baby, you might want to give Similac Sensitive a miss. 

Similac Sensitive can also foam when mixed. If your baby is struggling with gas, this foam isn’t ideal. Not all parents report the problem — some find Similac Sensitive mixes nicely — but it is something to be aware of. 

Fussiness Vs Lactose Sensitivity

It can be difficult to tell exactly what is causing an issue at feeding time. Babies can’t tell us what’s wrong! For that reason, choosing the right formula can feel like trial and error.

If you suspect lactose intolerance, we recommend giving Similac Sensitive a go. This is formulated specifically for babies struggling to digest lactose. The milk protein isolate essentially removes the lactose from the dairy.

But if you suspect a more general fussiness, then check out Enfamil Gentlease. By using partially hydrolyzed proteins, Enfamil has made the formula easier for tummies to digest.

And hydrolyzed proteins should also get to work quickly. Crying and fussing caused by feeding can potentially be reduced in under 24 hours. So, you can quickly see if Enfamil Gentlease is working for you!

Final Thoughts On Similac sensitive vs Enfamil Gentlease

It’s difficult to choose between Enfamil Gentlease and Similac Sensitive. Both infant formulas offer a complete feed for a sensitive stomach, and both come highly recommended by healthcare professionals.

Due to the lower price and easy mixing, Enfamil Gentlease is our top choice for sensitive stomachs. However, if your little one is struggling with lactose sensitivity, Similac Sensitive is the better choice.

All babies are different, and we think both brands are worth trying if you’re trying to fight fussiness!

And if you want to check out any more of our guides, we recommend checking out these guides on Nutramigen vs Alimentumhow to keep baby bottle warm at night and how to warm bottles on the go. Or even our guides for the best bottles for tongue tie, and best baby bottles for reflux, and best formula for colic and gas!

Similac Sensitive Infant Formula
$47.81 ($0.25 / Fl Oz)
05/23/2024 12:03 pm GMT
similac sensitive or enfamil gentlease