Similac Pro Total Comfort Vs Pro Sensitive

Are you trying to decide between Similac Pro Total Comfort Vs Pro Sensitive infant formula that won’t upset your baby’s sensitive stomach?

Then let us help you decide which is best low lactose baby formula with our Similac Pro Sensitive vs Total Comfort review!

When a baby isn’t happy with their formula, you’ll know about it! From gas, to spit-up, to general fussiness, babies have a way of letting us know when something isn’t right!

But finding a fix to the problem is rarely simple.

Similac Pro-Total Comfort and Similac Pro-Sensitive are two gentle low lactose infant formulas designed for easier digestion. Packed full of nutrients — but not packed full of lactose — these are complete formulas that support healthy growth.

In this guide, we’ll take a look at the similarities and differences between Pro-Total Comfort and Pro-Sensitive, as well as their pros and cons, so you can decide which Similac formula is better for your little one.

And if you love this Similac Total Comfort and Similac Sensitive Pro review, make sure to check out our guides on best formula that tastes like breast milk, Enfamil Gentlease vs Similac SensitiveEnfamil Sensitive Vs Gentlease and Enfamil Gentlease vs Neuropro! You may even like our review on Enfamil NeuroPro vs Similac Pro Advance!

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similac pro total comfort vs pro sensitive

Similac Pro-Total Comfort Vs Pro-Sensitive

Let’s start by taking a close look at Similac Pro-Total Comfort and Pro-Sensitive.

All About Similac Pro-Total Comfort

If your little one is fussing and crying after a feed, you want to deal with the problem as soon as possible. However, switching formula brands can be stressful.

It often takes a while to see any results, and you might be tempted to try a new brand before the old one has had a chance to work!

Similac Pro-Total Comfort does things differently, potentially easing your formula switch and soothing tummy problems. Pro-Total Comfort is an incredibly gentle formula, made using partially hydrolyzed whey protein.

Hydrolyzation breaks the proteins down, making them easier for the stomach to digest.

Not only is this delicate on the tummy, but it also means the formula gets to work quickly. You can potentially see colicky symptoms reduced in just one day.

Pro-Total Comfort is also packed full of good things for your child.

It contains the Similac exclusive blend of DHA, lutein, and vitamin E, supporting brain and eye development, Pro-Total Comfort also contains 2’-FL HMO, a prebiotic found in breast milk that helps develop the immune system. 

The only real issue is the powder has a tendency to clump. You might need to use some elbow grease to mix it properly. 


  • Made with partially hydrolyzed whey protein, which is easier for the body to digest.
  • Suitable for lactose sensitive tummies.
  • Fast acting, can potentially reduce colicky symptoms in just one day.
  • Contains 2’-FL HMO, for a strengthened immune system.
  • Contains a healthy blend of DHA, lutein, and other nutrients.


  • The formula has a tendency to clump, which can make it difficult to mix.

You may also like our guide on Similac Pro Advance vs Pro Total Comfort!

Similac Pro-Total Comfort Infant Formula
$269.94 $221.94 ($1.24 / Ounce)
02/24/2024 12:03 am GMT

All About Similac Pro-Sensitive

Similac Pro Sensitive

Similac Pro-Sensitive is an infant formula designed to support babies who suffer from lactose sensitivity.

The milk-based formula contains very low levels of lactose, so it’s easier for sensitive stomachs to digest. This can reduce fussiness and gas, making for happier feeding times.

Similac Pro-Sensitive has been created to resemble breast milk as closely as possible.

The formula contains a supportive blend of DHA, lutein, and vitamin E, for healthy brain and eye development. It also contains 2’-FL HMO, a prebiotic that strengthens the immune system.

What Similac Pro-Sensitive doesn’t contain is GMOs, artificial growth hormones, or palm olein oil. Parents can feel happy knowing this formula is carefully crafted to high standards. It’s also hospital approved!

With an easy to mix formula and a delicate, sweet taste, parents and babies both love Similac Pro-Sensitive. It does contain milk protein, which can be slightly harder to digest, but the overall formula is excellent for sensitive stomachs.


  • A milk-based formula designed with low lactose for easier digestion.
  • Contains a brain and eye supporting blend of DHA, lutein, and vitamin E. 
  • Contains 2’-FL HMO, for strengthened immune support.
  • A delicate and sweet taste that is popular with babies.
  • Non-GMO, and contains no artificial growth hormones or palm olein oil.


  • Pro-Sensitive contains milk proteins, which some babies struggle to digest. 

Available from

You may also like our review on Similac Sensitive vs Pro Sensitive and Similac Sensitive Vs Total Comfort!

Similarities And Differences Between Similac Pro-Total Comfort And Pro-Sensitive

Created for babies with sensitive stomachs, the gentle formulas of Similac Pro-Total Comfort and Pro-Sensitive have a lot in common!

In this section, we’ll look at the similarities and differences between the infant formulas. 

A Complete Formula For Supported Development

Whether you choose Similac Pro-Total Comfort or Pro-Sensitive, one thing is certain — you’ll be making a good choice for your baby!

Despite the differences, both of these formulas are crafted with a high degree of care, and packed with the nutrients your little one needs.

Pro-Total Comfort and Pro-Sensitive are both formulated with the Similac exclusive blend of DHA, lutein, and vitamin E. These ingredients support the development of the brain and eyes, and are found in breast milk.

Similac packs their infant formulas with a complete blend of nutrients, ensuring your child is getting what they need from their food.

Pro-Total Comfort contains slightly higher levels of calcium and potassium, but you can trust both formulas to prove the necessary good stuff.

Low Lactose

Lactose is a sugar found in dairy that many bodies struggle to digest. It can be a particular problem for young babies, especially as dairy forms the base of most formulas.

Lactose sensitivity can lead to fussiness, gas, spit-up, and other stomach issues. If you suspect your child might be lactose intolerant, speak to a pediatrician to find the right formula for you.

Similac Pro-Total Comfort is made using 100% whey protein that is partially hydrolyzed.

Low in lactose, this is easy for the body to digest.And because it’s already partially hydrolyzed (essentially, partly broken down), the body can digest it quickly.

Similac Pro-Sensitive is made from milk protein, treated to remove most of the lactose. There’s roughly 0.1 grams of lactose per 100 kcal of Similac Pro-Sensitive. 

Neither of these products are considered lactose free. However, both Similac Pro-Sensitive and Similac Pro-Total Comfort are considered suitable for lactose sensitivity and lactose intolerance.


As well as the Similac exclusive blend of nutrients, both the Pro-Total Comfort and Pro-Sensitive formulas are boosted by the addition of 2’-FL human milk oligosaccharide (HMO).

2’-FL HMO is a prebiotic that’s found in significant levels in breast milk. It supports the development of a healthy immune system, strengthening your child’s ability to fight against illness.

By including 2’-FL HMO, Similac have created formulas that closely resemble breast milk.

Breastfeeding isn’t the right choice for every family, but with Pro-Total Comfort and Pro-Sensitive, you know your little one is still getting the support they need.


We’ve spoken a lot about what’s in the formulas, so now it’s time to consider what they’ve left out. 

Both Pro-Total Comfort and Pro-Sensitive of non-GMO formulas — they contain no genetically modified ingredients.

Although GMO ingredients do have to pass strict standards before they can be sold, many parents are happier knowing a formula is GMO-free.

Pro-Total Comfort and Pro-Sensitive are also both free from artificial growth hormones. Research is ongoing into the effects of artificial growth hormones in babies, but many parents are happy to avoid them!

Finally, both formulas are free from palm olein oil. Palm olein oil can reduce the absorption of calcium. By leaving it out, you know your baby is getting more of the nutrients from their formula. 

Hydrolyzed Vs Non-Hydrolyzed

One of the defining differences between Similac Pro-Total Comfort and Pro-Sensitive is the base protein. Pro-Sensitive uses intact milk protein, while Pro-Total Comfort uses 100% whey protein that has been partially hydrolyzed.

Partially hydrolyzed means the proteins in the formula have already been partly broken down. This means your baby’s tummy has to do less work to break down and digest the proteins. 

When a body struggles to break down a protein, it can cause digestive problems such as gas and constipation.

Because the Pro-Total Comfort formula has already started the process, the body has less work to do, potentially preventing fussiness.

Pro-Total Comfort is also a fast acting formula, again thanks to the partially hydrolyzed whey protein.

While there’s typically an adjustment period when you switch formulas, the easy digestion of the Pro-Total Comfort can get to work in just one day. 

Ease Of Use

Similac Pro-Total Comfort and Pro-Sensitive are both available in powder form. They simply need to be mixed with water, and you’re ready to go!

However, some parents have reported occasional problems with the Similac Pro-Total Comfort. It can clump, which makes it harder to dissolve the formula in the water.

It isn’t impossible, and you can still mix up a nice bottle full for your hungry baby, but it might take a little longer.

It’s worth noting that not all parents have had this problem! Many have found Pro-Total Comfort mixes smoothly.

Final Thoughts On Similac Pro Sensitive vs Total Comfort

Trying to find the right formula for a fussy stomach? Both Similac Pro-Total Comfort and Pro-Sensitive are excellent choices. Packed full of nutrients, these gentle infant formulas can ease colicky symptoms, making feeding time more enjoyable.

Our top pick is the Pro-Total Comfort, thanks to the easy digestion of the partially hydrolyzed whey proteins. However, we also love the easy use formula of the Pro-Sensitive.

Both infant formulas are supportive choices for your little one! We hope this guide will help you find the perfect formula for happy feeds!

And if you want to check out any more of our guides, we recommend checking out these guides on does baby formula expire?, how to keep baby bottle warm at night and how to warm bottles on the go. Or even our guides for the best bottles for tongue tie, and best baby bottles for reflux and best formula for colic and gas!

Similac Pro-Total Comfort Infant Formula
$269.94 $221.94 ($1.24 / Ounce)
02/24/2024 12:03 am GMT
similac pro sensitive vs pro total comfort